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• A facile, controllable and low-cytotoxic
method of physically depositing and
stabilizing silk fifibroin using HFIP solvent
onto Ti biometal TC4 was established.
• The interface adhesion strength was de
termined through advanced centrifugal
measurement, and high silk fifibroin
(SF)-TC4 adhesion strength of 7 MPa
was achieved with optimized substrate
roughness (Ra~1 μm).
• The water wettability of TC4 was im
proved signifificantly with SF coatings.
• The SF-TC4 coating-substrate system
proved to improve osteoblast cell viabil
ity and growth.
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